46% type 2 diabetes remission. Structured caloric restriction. The DiRECT trial evidence.

Name: Lipoly
Brand: Lipoly

The Fat Loss Sprint is built on the same clinical approach that produced the most significant diabetes reversal data in decades.

See the evidence. Try 7 days free — lipoly.app

Critical Medical Disclaimer

This page must be handled carefully. Always include prominently: "If you take insulin, sulfonylureas, or other diabetes medications, you must speak with your prescribing doctor before starting. Rapid fat loss causes rapid glucose improvement — which means your medication doses will likely need adjustment. Proceeding without medical guidance creates hypoglycaemia risk."

The DiRECT Trial Evidence

The DiRECT trial (Lean et al., The Lancet, 2018 and 2019) is the landmark study in this space. 298 adults with type 2 diabetes were randomised to intensive dietary management (total diet replacement at 825–853 kcal/day) or standard care.

46% of the dietary intervention group achieved diabetes remission (HbA1c under 6.5% without medication)
24% lost 15 kg or more
Mean weight loss: 10 kg in the intervention group vs. 1 kg in standard care

36% of the intervention group maintained remission
The intervention group maintained significantly greater weight loss at every time point

These results exceeded surgical outcomes in some comparisons and represent the strongest evidence to date that type 2 diabetes can be reversed through structured dietary intervention — not just managed.

The Fat Loss Sprint is built on the same PSMF/VLCD science that underpins DiRECT.

Additional Diabetes Research

In their foundational PSMF study, insulin requirements in obese diabetic patients were withdrawn after a mean of 6.5 days of the protocol. Fasting glucose fell significantly.

Systematic review confirming VLCDs produce significant weight loss, improved HbA1c, improved fasting glucose, and improved cardiovascular risk profiles in type 2 diabetes.

Liver fat — a primary driver of hepatic insulin resistance — normalised within 7 days of starting intensive caloric restriction.

Why the FLS Is Appropriate for This Audience

Visceral fat (most metabolically harmful in diabetes) is preferentially mobilised during severe restriction
Deep ketosis acutely improves insulin sensitivity within days
Very low carbohydrate intake directly reduces post-prandial glucose spikes
Rapid weight loss produces faster glycaemic improvement — relevant for people at high cardiovascular risk
Defined duration (14–28 days) is manageable for people already managing a chronic condition

Medication Warning

Rapid fat loss causes rapid improvements in blood glucose. If you take insulin, sulfonylureas (glipizide, glibenclamide, gliclazide), or SGLT-2 inhibitors, your doses will very likely need reduction during the sprint. Proceeding without medical supervision creates serious hypoglycaemia risk.

This is a good problem to have — it means the protocol is working — but it requires your prescribing doctor's involvement before and during the sprint.

The dietary protocol behind the most significant diabetes reversal data in decades.

See the research. Try 7 days free — lipoly.app

If you take diabetes medications, speak to your doctor before starting.

See your numbers

Run the calculator on your own stats.

Sprint level, calculated macros, and a recommended duration — based on your body composition.

Sprint Level 1

Lean Body Mass: — kg

🥩

—g

Protein

🥑

—g

Fat

🌾

—g

Carbs

🔥

—

Calories

Recommended: —

Training

2× strength training per week
8–10K steps daily
No running or HIIT

See My Full Plan →

Free 7-day trial · No charge today · Cancel anytime

Important information

The information on this page is for general educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Lipoly is a self-guided informational tool — it is not a medical intervention, medical device, or supervised clinical program, and does not replace professional medical care.

Always consult a qualified medical professional before starting any new diet, exercise, or supplementation protocol — particularly if you have a pre-existing health condition, take prescription medication, or are pregnant or breastfeeding. Individual results vary based on body composition, adherence, sex, age, and other factors.

Lipoly is not suitable for: pregnancy, breastfeeding, type 1 diabetes, active eating disorders, severe kidney or liver disease, or body fat below 12% (male) / 18% (female). See full eligibility criteria and contraindications in the app.

Any comparisons with third-party products, services, medications, or approaches on this page are based on publicly available information and provided for informational purposes only. Lipoly makes no claim that any named product or service is unsafe, ineffective, or unsuitable — only that the Fat Loss Sprint is a different tool designed for a different purpose. Prices and product features of third-party services are approximate, based on publicly available data, and subject to change; verify current details at the respective provider's website.

If you are currently taking prescription medication — including GLP-1 agonists, insulin, sulfonylureas, SGLT-2 inhibitors, or any other weight-related or metabolic medication — do not stop, reduce, or substitute your medication without guidance from your prescribing doctor. Rapid metabolic changes during a structured dietary protocol may require medication dose adjustment and must be managed under medical supervision.